health
silvermouse
Posts: 21,088 ✭✭✭✭✭
a thread to park studies related to good health. Here's one related to a food additive, usually labeled 'emulsifier':
Ubiquitous food additive alters human microbiota and intestinal environment
New clinical research indicates that a widely used food additive, carboxymethylcellulose, alters the intestinal environment of healthy persons, perturbing levels of beneficial bacteria and nutrients.
.....
" Carboxymethylcellulose (CMC) is a synthetic member of a widely used class of food additives, termed emulsifiers, which are added to many processed foods to enhance texture and promote shelf life."
https://www.sciencedaily.com/releases/2021/11/211130130223.htm
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Comments
Jesus Christ Edward, worried me with the title
Sorry, didn't think of that. Can't change the title to avoid concern. Anyway, being an immortal alien there is never a need to be concerned about me.
Actual animal fat used to be used as emulsifiers in foods. Now, like so many other things, those fats were deemed unhealthy so they began making them in a laboratory instead. We know how that usually works out. Whenever you can, go with nature.
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The 2nd time I read it made it sink in
I'm always skeptical of studies like this for one major reason: The dose makes the poison.
Digging in to the study behind the article, looking at the Methods section:
"To examine this notion in humans, we performed a double-blind controlled feeding study of the ubiquitous synthetic emulsifier carboxymethylcellulose (CMC) in which healthy adults consumed only emulsifier-free diets (n=9) or an identical diet enriched with 15 grams per day of CMC (n=7) for 11 days."
The amount of CMC used in Ice Cream (one of many products CMC can commonly be found in - although it's also important to note that natural emulsifiers like Lecithin are also very commonly used) is generally around 0.5% by weight.
If we calculate this out, someone would have to eat 3000 grams (pleas check my math) or 6.6 pounds of ice cream each day to reach that 15 grams (assuming the ice cream you choose contains CMC and the % by weight is 0.5%).
Always important to dig in a little deeper to see what these studies are actually studying.
Oh crap! 6.6 lbs a day? I come close to that some days! But mine doesn’t have cmc in it, so I’m good! All my stabilizer and/or emulsifiers are natural, along with my flavorings.
I volunteer for that study.
It’s science bro, you are not supposed to argue with it.
Better living through chemistry.
Don't let the wife know what you spend on guns, ammo or cigars.
We avoid the fat, salt and sugar the fast food industry produces. We grow most of our veggies and get eggs, pork, beef and chicken from a small ( they have 200 chickens) sustainable family owned farm. I also read a lot of labels at the grocery store. Big, corporate food producers are not your friends.
Eat more moose. 50,000 wolves can’t be wrong.
Thanks for getting this thread started, @Amos_Umwhat, I think it will be a fun and potentially educational one. My wife and I try to stay away from foods that aren't natural. That being said, we do also enjoy the occasional fast-food or frozen pizza. Each summer I grow a small garden of veggies, I have been considering upping the size of this garden and trying to become more self-sustaining.
All of this lockdown stuff put into perspective just how much we tend to suckle at the teats of corporations and governments. Which leaves a bad taste in my mouth...probably from too much soy or something...
"Iron sharpens iron, and one man sharpens another." - Proverbs 27:17
I’m trying bro…. I’m trying
FIFY
"If you do not read the newspapers you're uninformed. If you do read the newspapers, you're misinformed." -- Mark Twain
I walk about two and a half miles every morning rain, snow, or shine. Try to get my heart rate up to 100- 110 and keep it there. Takes about 45 minutes of walking to earn my after dinner cigar. I have a full set of dumbbells. a bench, and a pulldown machine in my studio that I try to get to for a half hour three days a week. I've been working out in some way or another most of my 75 years. Use it or loose it.
Sorry, @silvermouse and @Amos_Umwhat, I guess all you old codgers just start looking alike after a while.
"Iron sharpens iron, and one man sharpens another." - Proverbs 27:17
Good health is somewhat dependent on what you eat. You are what you eat. If you don't know how to cook I think you should learn. Food that you cook yourself is much better for you than prepared food. Cooking takes time and time is valuable. A good cook book will save you time and provide creative ways of making good eats. A classic favorite of mine is The Joy Of Cooking by Rombauer and Becker. Copyright 1931 with the current edition 2006. 1132 pages of time tested recipes. I bluffed my way into a cooking job years ago with this book under my arm. It saved my as s . The new current edition has a lot of ethnic sections. So I suggest that if you like to eat good food learn how to make it yourself.
https://www.sciencealert.com/giant-study-finds-****-is-linked-to-almost-70-lower-risk-of-alzheimer-s
I tried to access the original study but it is behind a paywall.
Joy of Cooking has been my primary source of cooking information forever.
"If you do not read the newspapers you're uninformed. If you do read the newspapers, you're misinformed." -- Mark Twain
Eating shlt lowers risk of Alzheimer's? I think I'll take the memory loss.
Trapped in the People's Communist Republic of Massachusetts.
now the censor-bot is modifying links???? it was 'v i a g r a', not shlt. There, that might change your mind Shawn.
here's an abstract of the paywalled study:
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease
Jiansong Fang, Pengyue Zhang, Yadi Zhou, Chien-Wei Chiang, Juan Tan, Yuan Hou, Shaun Stauffer, Lang Li, Andrew A. Pieper, Jeffrey Cummings & Feixiong Cheng
Nature Aging (2021)Cite this article
143 Altmetric
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Abstract
We developed an endophenotype disease module-based methodology for Alzheimer’s disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier. Based on retrospective case–control pharmacoepidemiologic analyses of insurance claims data for 7.23 million individuals, we found that sildenafil usage was significantly associated with a 69% reduced risk of AD (hazard ratio 0.31, 95% confidence interval 0.25–0.39, P < 1.0 × 10–8). Propensity score-stratified analyses confirmed that sildenafil is significantly associated with a decreased risk of AD across all four drug cohorts tested (diltiazem, glimepiride, losartan and metformin) after adjusting for age, sex, race and disease comorbidities. We also found that sildenafil increases neurite growth and decreases phospho-tau expression in neuron models derived from induced pluripotent stem cells from patients with AD, supporting mechanistically its potential beneficial effect in AD. The association between sildenafil use and decreased incidence of AD does not establish causality, which will require a randomized controlled trial.
Now I have a use for all that Via-gra in the medicine cabinet.
Trapped in the People's Communist Republic of Massachusetts.
Now?
"If you do not read the newspapers you're uninformed. If you do read the newspapers, you're misinformed." -- Mark Twain
You forgot what it was used for?
I’ve got a buddy who uses it in 1/2 doses for a pre workout before the gym.
Didn't you know? Male heterosexuality is actively frowned upon by the "woke".
"If you do not read the newspapers you're uninformed. If you do read the newspapers, you're misinformed." -- Mark Twain
Toxic
I know, You're a big dog and I'm on the list.
Let's eat, GrandMa. / Let's eat GrandMa. -- Punctuation saves lives
It'll be fine once the swelling goes down.
https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5984069&blobtype=pdf
Dietary trehalose enhances virulence of epidemic Clostridium
difficile
Discussion
Containing an α,α-1,1-glucoside bond between two α-glucose units, trehalose is a nonreducing and extremely stable sugar, resistant to both high temperatures and acid hydrolysis.
Although considered an ideal sugar for use in the food industry, the use of trehalose in the
US and Europe was limited prior to 2000 due to high cost of production (~$700 Kg−1). The
innovation of a novel enzymatic method for low cost production from starch made it
commercially viable as a food supplement (~$3 Kg−1).18 Granted GRAS (Generally
Recognized As Safe) status by the FDA in 2000 and approved for use in food in Europe in
2001, reported expected usage ranges from concentrations of 2%-11.25% for foods
including pasta, ground beef, and ice cream. The widespread adoption and use of trehalose
in the diet coincides with the emergence of both RT027 and RT078 outbreaks (Fig. 6).
Several lines of evidence support that dietary trehalose has participated in the spread of
epidemic C. difficile ribotypes. First, the ability of RT027 and RT078 strains to metabolize
trehalose was present prior to epidemic outbreaks. The earliest retrospectively recorded
RT027 isolate was the non-epidemic strain CD196, isolated in 1985 in a Paris hospital.19
Three years later in 1988, another non-epidemic strain RT027 (BI1) was isolated in
Minneapolis, Minnesota. Both isolates, in addition to every RT027 strain sequenced to date,
contain the L172I substitution in TreR. RT078 strains were also present in humans prior to
2001, but epidemic outbreaks were not reported until 2003.4
Second, RT027 and RT078
lineages are phylogenetically distant clades of C. difficile, yet have convergently evolved
distinct mechanisms to metabolize low levels of trehalose. Third, increased disease severity
of a RT027 strain that can metabolize trehalose in our CDI mouse model is consistent with
increased virulence of RT027 and RT078 ribotypes observed in patients. Fourth, the ability
to metabolize trehalose at lower concentrations confers a competitive growth advantage in
the presence of a complex intestinal community. Finally, levels of trehalose in ileostomy
Collins et al. Page 5
Nature. Author manuscript; available in PMC 2018 July 03.
Author Manuscript Author Manuscript Author Manuscript Author Manuscript
fluid from patients eating a normal diet are sufficiently high to be detected by RT027 strains.
Based on these observations, we propose the widespread adoption and use of the
disaccharide trehalose in the human diet has played a significant role in the emergence of
these epidemic and hypervirulent strains.20
https://healthjade.com/trehalose/
Contents [hide]
What is trehalose
Is trehalose a reducing sugar?
What is trehalose used for?
Trehalose sources
Chemical synthesis of trehalose
Trehalose in food
Trehalose side effects
In English?