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@peter4jc said:
The self-help guru who decided he might be doing more harm than good
https://www.telegraph.co.uk/news/2026/03/09/tim-ferriss-self-help-may-be-harming-people/
I found the original self-help guru's blog post that this article was based on more understandable and interesting.
Join us on Zoom vHerf (Meeting # 2619860114 Password vHerf2020 )0 -
A certain aging gut bacteria may cause some amount of cognitive decline
Intestinal interoceptive dysfunction drives age-associated cognitive decline
Abstract
Ageing is accompanied by declining memory function, with extremely heterogeneous manifestation in the human population1. Brain-extrinsic factors influencing cognitive decline, such as gastrointestinal signals, have emerged as attractive targets for peripheral interventions2,3,4,5,6, but the underlying mechanisms remain largely unclear. Here, by charting a high-resolution map of microbiome ageing and its functional consequences throughout the lifespan of mice, we identify a mechanism by which inhibition of gut–brain signalling during ageing results in impaired neuronal activation in the hippocampus and loss of memory encoding. Specifically, accumulation of gut bacteria that produce medium-chain fatty acids, such as Parabacteroides goldsteinii, can drive peripheral myeloid cell inflammation through GPR84 signalling. As a result, the function of vagal afferent neurons is impaired, the interoceptive signal received by the brain is weakened and hippocampal function declines. We leverage this pathway to define interventions that enhance memory in aged mice, such as phage targeting of Parabacteroides, GPR84 inhibition and restoration of vagal activity. These findings indicate a key role for interoceptive dysfunction in brain ageing and suggest that interoceptomimetics that stimulate gut–brain communication may counteract age-associated cognitive decline.2 -
"The Deep Blue Good-by a Travis McGee novel by John D. MacDonald. 1964 One of a series by a grand master of detective fiction.
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The start of Cyberdyne and Skynet
https://www.wsj.com/business/entrepreneurship/rivian-ceos-ai-powered-robotics-startup-raises-500-million-0edc0209If it don’t bother me, it don’t bother me. Just leave me alone.
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