What are you reading?
Comments
-
Toxic Exposure Can Trigger Disease for 20 Generations
Summary: A single exposure to a common fungicide during pregnancy can haunt a family line for 20 subsequent generations, according to a staggering new study. The research found that health problems—including kidney, prostate, and reproductive issues—not only persisted but actually worsened centuries later in “human time.
By the 15th generation, the pathology became lethal, with high rates of death during birth for both mothers and offspring. This discovery of “epigenetic transgenerational inheritance” suggests that many modern chronic diseases may be rooted in the environmental exposures of ancestors who lived hundreds of years ago.
Key Facts
The 20-Generation Span: Disease risk from a single toxic exposure remains stable for at least 20 generations, equivalent to roughly 500 years in humans.
Lethal Progression: While disease rates stayed steady for the first 14 generations, they surged around the 15th, leading to severe abnormalities and death during the birth process.
Germline Programming: Once a toxin alters the reproductive cells (sperm or egg), the change becomes as stable and permanent as a genetic mutation.
Low-Dose Impact: The study used conservative toxin levels—lower than what the average person might consume in their daily diet.
Preventative Potential: Despite the daunting timeline, researchers have identified epigenetic biomarkers that can predict these disease susceptibilities 20 years before they develop, offering a window for preventative medicine.https://neurosciencenews.com/epigenetic-toxic-inheritance-30155/
2 -
Amazon’s CEO just made a scary prediction for 2026. Economists worry he’s right
"No matter what you might hear coming out of the White House, realistically, those options do not somehow magically include getting foreign suppliers to shoulder the cost of tariffs. A new study by the Kiel Institute in Germany found that a whopping 96% of the costs of tariffs are passed on to U.S. importers and consumers. "
0 -
Fortune
235.9K Followers
Ex-presidential candidate Andrew Yang warns that millions of white-collar workers will lose their jobs within 18 months: 'The AI jobpocalypse is here'
Story by Preston Fore •Entrepreneur and ex–presidential candidate Andrew Yang warns AI is about to gut millions of office jobs.
Entrepreneur and ex–presidential candidate Andrew Yang warns AI is about to gut millions of office jobs.
© JP Yim/Getty Images for The Asian American Foundation
The artificial intelligence boom has fueled grand promises: cures for cancer, self-driving metropolises, and even interplanetary travel. It’s also powered a stock market surge that’s padded plenty of retirement accounts. But beneath the optimism, entrepreneur and former presidential candidate Andrew Yang says a far more immediate disruption is underway—and the U.S. is not ready for it.“I believe that millions of white-collar workers are going to lose their jobs in the next 12 to 18 months due to AI,” Yang said in an Instagram video that’s garnered over 600,000 views.
“AI is now able to do the work of a very, very smart human in minutes or even seconds. This is going to displace marketers, coders, designers, lawyers, accountants, call center workers—you name it.”
Yang joins a chorus of business leaders—from Anthropic CEO Dario Amodei to Ford CEO Jim Farley—warning about the nightmare that could be coming for white-collar workers. However, the economic fallout in reality could reach far beyond office workers.
“When people lose their jobs, it affects dry cleaners, dog walkers, hairstylists, restaurants—all local businesses that see less people who are able to spend. Personal bankruptcies are going to surge,” Yang added.
The end result, the 51-year-old said, will be a more extreme winner-take-all economy, where the path to social mobility and middle-class status is “broken.”
·
Ad
call to action icon
more
“The AI job apocalypse is real,” Yang said. “It’s underway right now.”0 -
Glad he finally caught on. I said this well over a year ago lol
If it don’t bother me, it don’t bother me. Just leave me alone.
2 -
Be nice if Congress caught on.
meanwhile:
A Boston Celtics game-inspired friction test finally pinned down why sneakers squeak
https://www.wbur.org/news/2026/02/26/why-basketball-sneakers-squeak-boston-research
1 -
-
Thank you, informative essay. ^^^
0 -
"Gathering Prey" by John Sandford. Found this at our local library.
1 -
If you take a tyrosine supplement to boost mental acuity it will shorten your life span by 0.91 years. But only in males.
The role of phenylalanine and tyrosine in longevity: a cohort and Mendelian randomization study
https://www.aging-us.com/article/206326/text
Abstract
Background: Protein restriction increases lifespan, however, the specific amino acids affecting lifespan are unclear. Tyrosine and its precursor, phenylalanine, may influence lifespan through their response to low-protein diet, with possible sex disparity.Methods: We applied cohort study design and Mendelian randomization (MR) analysis. Specifically, we examined the overall and sex-specific relationships between circulating phenylalanine and tyrosine and all-cause mortality in the UK Biobank using **** regression. To test causality, in two-sample MR analysis, we used genetic variants associated with phenylalanine and tyrosine in UK Biobank with genome-wide significance and uncorrelated (r2 < 0.001) with each other, and applied them to large genome-wide association studies of lifespan, including parental, paternal, and maternal attained ages in the UK Biobank. We also conducted multivariable MR to examine the independent role of phenylalanine and tyrosine.
Results: Tyrosine was associated with shorter lifespan in both observational and MR study, with potential sex disparity. After controlling for phenylalanine using multivariable MR, tyrosine remained related to a shorter lifespan in men (−0.91 years of life, 95% confidence interval (CI) −1.60 to −0.21) but not in women (−0.36 years, 95% CI −0.96 to 0.23). Phenylalanine showed no association with lifespan in either men or women after controlling for tyrosine.
Conclusions: Reducing tyrosine in people with elevated concentrations may contribute to prolonging lifespan, with potential sex-specific differences. It is worthwhile to explore pathways underlying the sex-specific effects.
1
