Best Of

That's only because Trump fired the lady who puts the numbers together and replaced her with someone who would tell him what he wants to hear.

So, you're saying @VegasFrank was in British Colombia?

https://notthebee.com/article/campers-call-in-search-and-rescue-after-hearing-screaming-in-the-woods-it-turned-out-to-be-some-guy-singing-nickleback?from_social=twitter

"One of the main discoveries in the study is that as amyloid beta begins to form deposits in the early stages of dementia in both humans and mouse models, it binds to lithium, reducing lithium’s function in the brain. The lower lithium levels affect all major brain cell types and, in mice, give rise to changes recapitulating Alzheimer’s disease, including memory loss.

The authors identified a class of lithium compounds that can evade capture by amyloid beta. Treating mice with the most potent amyloid-evading compound, called lithium orotate, reversed Alzheimer’s disease pathology, prevented brain cell damage, and restored memory.

Although the findings need to be confirmed in humans through clinical trials, they suggest that measuring lithium levels could help screen for early Alzheimer’s. Moreover, the findings point to the importance of testing amyloid-evading lithium compounds for treatment or prevention.

Other lithium compounds are already used to treat bipolar disorder and major depressive disorder, but they are given at much higher concentrations that can be toxic, especially to older people. Yankner’s team found that lithium orotate is effective at one-thousandth that dose — enough to mimic the natural level of lithium in the brain. Mice treated for nearly their entire adult lives showed no evidence of toxicity.

“You have to be careful about extrapolating from mouse models, and you never know until you try it in a controlled human clinical trial,” Yankner said. “But so far the results are very encouraging.”

https://www.newswise.com/articles/could-lithium-explain-and-treat-alzheimer-s-disease/

From 1440:

OceanGate Implosion Findings

The US Coast Guard released its report yesterday on the 2023 OceanGate submersible implosion, concluding the disaster was preventable and directly caused by the company’s disregard for safety protocols. The Titan submersible imploded in the Atlantic Ocean during a paid trip to explore the Titanic wreck, killing all five passengers on board.

The 335-page report identifies eight primary engineering failures and four contributing factors, finding that OceanGate’s leadership dismissed safety concerns, failed to properly test and certify the vessel, and intimidated employees who raised alarms—including by filing a SLAPP lawsuit against a whistleblower. The company operated Titan outside accepted deep-sea safety standards and exploited regulatory loopholes, neglecting independent certification and adequate life-cycle safety checks. Cost-cutting measures also likely compromised safety, such as storing Titan outdoors in the Canadian winter and using only four bolts to secure the forward dome instead of the required 18. See design choices here.

The report is separate from the National Transportation Safety Board investigation, which is expected to release its findings later this year.