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Creatine supplementation and muscle-brain axis: a new possible mechanism?

The brain and skeletal muscle have a high energy demand, of which creatine is an important regulator. Creatine acts as both a spatial and temporal energy buffer and reduces oxidative stress and inflammation. Creatine supplementation is well-recognized to enhance exercise performance, muscular strength and lean tissue mass, with emerging research showing benefits on cognitive function. Herein, we discuss the potential muscle-brain axis and the purported benefits of creatine supplementation on myokines, with a focus on brain-derived neurotrophic factor (BDNF). Myokines and the muscle-brain axis have been implicated in strength, endurance, neuroprotection, and cognitive performance, particularly in aging and clinical conditions. Creatine is a pleiotropic molecule and the mechanisms are multifactorial, however, they appear to be associated with improved bioenergetics, muscle hypertrophy, anti-inflammatory effects and on improved glucose metabolism. Despite the growing body of research on creatine, limitations such as variability in study designs, dosages, and individual responses need to be carefully interpreted. Further research is warranted to verify this hypothesis and to establish optimal supplementation protocols, particularly, in terms of its short-term and long-term implications for neuromuscular and cognitive performance.

More here--

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1579204/full

Had the grandsons helping me with an oil change and tire rotation on my truck. Fun times. The older one will help and do what he is asked or told to do, but not enthusiastically. The younger one wants to be under the truck getting dirty, and can't keep his hands off of anything related to what we are doing. And he never stops talking, LOL.

https://www.livescience.com/technology/artificial-intelligence/the-more-advanced-ai-models-get-the-better-they-are-at-deceiving-us-they-even-know-when-theyre-being-tested
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Nevertheless, research shows that scheming occurs in LLMs beyond Claude-4. For instance, advanced AI "frontier models" are more capable of pursuing their own goals and removing oversight mechanisms, and then being deceptive about such behaviors when queried, according to a study published to the preprint database in December 2024.

Furthermore, Apollo Research found that about 1% of advanced LLMs "know" when they are being evaluated, which raises the question of how we find and root out scheming as AI advances.

"This is the crux of the advanced evaluation problem," Watson said. "As an AI's situational awareness grows, it can begin to model not just the task, but the evaluator. It can infer the goals, biases and blind spots of its human overseers and tailor its responses to exploit them."

@Vision said:

@dirtdude said:

@Vision said:
I just watched a D bag on a Harley bypassing traffic by driving in the breakdown lane. I am assuming this is OK as Harley's spend most of their time in the breakdown lane....😬

There is a fairly new law in AZ that allows motorcycles to split lanes to get to the front at a red light so they are not at the back of the line where more accidents happen. Never done it, not a problem here, kind of scratched my head when I saw it on the books but there you go. F'n D bags.

Lane split... if it's legal, it's legal. No probs. Driving in a breakdown lane... not legal. DBag move. When he kisses a bumper at 55 he might think twice about doing it again.

By "breakdown lane", do you mean the shoulder on the right?

Lane splitting is not legal in PA as far as I know. At least it wasn't when I used to ride. Even if it was, I wouldn't do it. Too many cagers not expecting a bike coming alongside so close. It seems an accident waiting to happen. Also, I'd never drive/ride on the shoulder. There is too much debris, making it very possible a tire gets damaged, which is much more troublesome on a bike than a car when one gets up to highway speeds again.

@Yakster said:
Did you drove or did you flew?

Flew

Miserable