Best Of
Re: Whatcha smokin this morning?
Thank you Shawn. Too many people frantically relaxing at the beach, the smell of sun tan oil, music, noise. Summer in a tourist town isn't the best time to enjoy nature here.
Re: What are you reading?
Something as miniscule as a virus is capable of reshaping our DNA amazes me.
https://www.nature.com/articles/s41467-025-60534-6
Article
Open access
Published: 19 June 2025
Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking
Esther González-Almela, Alvaro Castells-Garcia, François Le Dily, Manuel Fernández Merino, Davide Carnevali, Pol Cusco, Luciano Di Croce & Maria Pia Cosma
Nature Communications volume 16, Article number: 5313 (2025) Cite this article
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Abstract
Herpes simplex virus type 1 (HSV-1) remodels the host chromatin structure and induces a host-to-virus transcriptional switch during lytic infection. We combine super-resolution imaging and chromosome-capture technologies to identify the mechanism of remodeling. We show that the host chromatin undergoes massive condensation caused by the hijacking of RNA polymerase II (RNAP II) and topoisomerase I (TOP1). In addition, HSV-1 infection results in the rearrangement of topologically associating domains and loops, although the A/B compartments are maintained in the host. The position of viral genomes and their association with RNAP II and cohesin is determined nanometrically. We reveal specific host–HSV-1 genome interactions and enrichment of upregulated human genes in the most contacting regions. Finally, TOP1 inhibition fully blocks HSV-1 infection, suggesting possible antiviral strategies. This viral mechanism of host chromatin rewiring sheds light on the role of transcription in chromatin architecture.
Re: Cooler
@MichaelK said:
This is why I came here, to learn a lil something. I would never dismiss advice based off experience. You learn from mistakes and from others who know.
One of the biggest things you have to consider is the environment that you’re keeping your cigars in. Do you live in a hot and humid climate? Does it stay fairly stable year round? Where in the house are you storing your cigars? Does the temperature vary a lot in that room? All of these thing play a part in what the best way to store them actually is.
And another thing….don’t fret over humidity. Hygrometers measure rh in the air…not the moisture content of your cigars. Humidity is also measured as rh, which is relative humidity. It’s relative to the temperature in said environment.
Cigars are much more resilient than most people give them credit for. Don’t worry about reaching what a lot of people claim are perfect numbers for this and that. Worry about reaching what works for you and getting the best experience you can out of YOUR cigars and setup.
Rdp77
Re: Whatcha smokin this morning?
A little Villiger quick smoke, not 'orrible, not great.
Re: What are you reading?
Former World Bank chief economist warns of dollar crash
INSIDE USA • Albert Steck
Former World Bank chief economist warns of dollar crash
In an NZZ interview, Harvard debt-crisis expert Carmen Reinhart says more global economic shocks are likely. A crash in the dollar's value is «absolutely» possible, she adds. The primary culprit? Skyrocketing U.S. debt, she says.
https://www.nzz.ch/english/former-world-bank-chief-economist-warns-of-dollar-crash-ld.1889335
Re: What are you reading?
But the way these products work—receiving instructions from users and then scouring the internet for answers—creates a ton of new risks. With AI, they could be used for all sorts of malicious tasks, including leaking people’s private information and helping criminals phish, spam, and scam people. Experts warn we are heading toward a security and privacy “disaster.”
Here are three ways that AI language models are open to abuse.
https://www.technologyreview.com/2023/04/03/1070893/three-ways-ai-chatbots-are-a-security-disaster
Re: 2025 MKE Herf
2-Day conference, Wednesday and Friday. But we don't work on federal holidays.
Itsfine
Re: TNBigfoot's Rock Throw Contest 2025
Sorry guys, I need to put off the contest for now. I am not in the right frame of mind at the moment and don't have the time and desire to do it the right way at the moment. Give me a couple of months hopefully.
