@ShawnOL said:
I used to buy albums as they came out
and had a decent collection of cassettes. Fast forward many years and im rebuilding my collection with cds. Next two bands to buy up: kiss and Metallica. What should I buy next?
Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization
Highlights
Aging induces cytoplasmic localization of angiogenin to produce Glu-5′tsRNA-CTC
Glu-5′tsRNA-CTC disrupts mitochondrial translation and cristae organization
Cristae ultrastructure is required to maintain glutamate homeostasis in the brain
ASO targeting Glu-5′tsRNA-CTC rescues memory decline in aged mice
Struggling with this now, so I find it informative, got to be my own advocate.
European Society of Endocrinology and Endocrine Society Joint Clinical Guideline: Diagnosis and Therapy of Glucocorticoid-induced Adrenal Insufficiency
"A recent study reports something strange: When mice with Alzheimer's disease inhale menthol, their cognitive abilities improve. It seems the chemical compound can stop some of the damage done to the brain that's usually associated with the disease."
@silvermouse said:
"A recent study reports something strange: When mice with Alzheimer's disease inhale menthol, their cognitive abilities improve. It seems the chemical compound can stop some of the damage done to the brain that's usually associated with the disease."
Organisms in sauerkraut protect gut against antibiotics
The minuscule viruses that infect beneficial bacteria living in sauerkraut can be used to help maintain a healthy gut during treatment with antibiotics, a new study in mice suggests.
Yogurt is often thought of as a good source of healthy bacteria for the gut. All bacteria, including those in our intestines and in the food we eat, are infected by such viruses, known as phages.
Sauerkraut contains even more bacteria than yogurt, as long as it has not been pasteurized or treated with preservatives, the researchers said in a presentation at the Digestive Disease Week meeting in Washington.
To make the sauerkraut, researchers fermented cabbage in a salt solution, then removed the bacteria from the sauerkraut juice and purified the phages.
Next, the researchers gave antibiotics to mice, to disrupt the balance of their healthy gut bacteria. Antibiotics typically kill off healthy bacteria and leave room for disease-causing bacteria to take their place, explained study leader Cristina Coffman of The Biomedical Research Institute of New Mexico in Albuquerque.
A few days later, some of the mice were fed the bacteria-infecting viruses from the sauerkraut juice, in their drinking water. Two weeks later, proportions of healthy gut bacteria were found to be depleted in the untreated mice, but the sauerkraut phages had prevented this disruption in the treated mice, the researchers found.
“In addition to this effect on the microbiome, sauerkraut (phages) also had an interesting biologic impact” the researchers said. Weight gain associated antibiotic treatment appeared to be blocked by sauerkraut phages, they said.
The researchers tested a mixed population of phages against the effects of five different antibiotics, Coffman said.
“We are hoping to learn more about how the phages shape the bacteria populations in the intestines and to find therapeutic uses for the phages,” Coffman said.
"In a decade’s time, we may look back at 2024 as the golden age of the web, when most of it was quality human-generated content, before the bots took over and filled the web with synthetic and increasingly low-quality AI-generated content."
Ticketmaster hacked. Breach affects more than half a billion users.
Emails, phone numbers, addresses, and even financial details have allegedly been exposed by a notorious hacker group.
"Shifting gears to another key point in the book: democracy, which you describe as the one form of government that allows the possibility of change without violence. But you also admit, and this is a quote: “Our governance systems—long ago co-opted as instruments for amplified personal power— have become nearly useless, at all levels, from the United Nations to the local city council. Institutions established during 450 generations of unresolvable conflict cannot facilitate change because they are designed to be agents of social control, maintaining what philosopher John Rawls called ‘the goal of the well-ordered society.’ They were not founded with global climate change, the economics of well-being, or conflict resolution in mind.”
So what you are essentially saying here is that anyone trying to adopt the Darwinian principles that you and Sal are advocating is going to be going up against established societal structures, which makes you, by definition, an enemy of the state.
Bronstein described the affected sea urchin species as the "lawn mowers" of coral reefs, since they remove algae that otherwise blocks sunlight, allowing the coral to thrive.
In the Gulf of Aqaba, no other creature has taken over that role and Bronstein's team is already seeing extensive growth in algae cover.
"When mortalities started in the Red Sea, they were so strong and so abrupt and so violent that the first thoughts were this must be some kind of pollution, or something very severe but very local," he said.
Then the phenomenon was seen at a wharf farther south in Sinai where a ferry from Aqaba docks. Two weeks later it spread another 70 kms (44 miles). They described thousands of skeletons of the once dominant species rolling on the sea bottom.
There is no known way to stop the disease, Bronstein said. But there is still a chance to create an isolated population, or broodstock, of the sea urchins remaining elsewhere that could hopefully be reintroduced later on.
Mathematicians Are Excited About a Newly Discovered Shape
The unique geometric shape maintains a constant width regardless of the dimension it's measured in.
As reported by New Scientist, at higher dimensions the shape will be proportionally smaller than the sphere of the equivalent dimension. And as New Scientist also points out, the shape can roll smoothly like a wheel even though it’s not round.
There's a wiki history page on Wanklel engines. Interesting read. I found this application interesting...
"The Wankel design is used in the seat belt pre-tensioner system[205] in some Mercedes-Benz[206] and Volkswagen[207] cars. When the deceleration sensors detect a potential crash, small explosive cartridges are triggered electrically, and the resulting pressurized gas feeds into tiny Wankel engines, which rotate to take up the slack in the seat belt systems, anchoring the driver and passengers firmly in the seat before a collision.[208]" https://en.wikipedia.org/wiki/Wankel_engine
"About 13.8 billion years ago, the entire cosmos consisted of a tiny, hot, dense ball of energy that suddenly exploded.
That’s how everything began, according to the standard scientific story of the Big Bang, a theory that first took shape in the 1920s. The story has been refined over the decades, most notably in the 1980s, when many cosmologists came to believe that in its first moments, the universe went through a brief period of extraordinarily fast expansion called inflation before settling into a lower gear.
That brief period is thought to have been caused by a peculiar form of high-energy matter that throws gravity into reverse, “inflating” the fabric of the universe exponentially quickly and causing it to grow by a factor of a million billion billion in less than a billionth of a billionth of a billionth of a second. Inflation explains why the universe appears to be so smooth and homogeneous when astronomers examine it at large scales.
But if inflation is responsible for all that can be seen today, that raises the question: What, if anything, came before?"
Right now " Broken Prey " by John Sandford.
Tried to read a new Reacher book " The Secret" by Lee Child's son Andrew Child. Well, Andrew ain't got the writing skill as his dad. Lost interest after two chapters.
"We are at risk of losing this essential capability that I call receptivity,” says Davis, the managing director of Toronto-based leadership consulting firm Russell Reynolds Associates. “It’s the ability to have good judgment, to have insight about people, and it’s a major concern.”
Technology, social media and artificial intelligence are to blame, Davis adds: People rely so much on their their phones that they’re increasingly unable to make judgment calls on their own. “It’s a cognitive ability that you need to actually exercise in order to not lose it,” he says.
"In truth, it can only ever be a happier ending. Of course, every kid who escapes institutional care to grow up in a loving adoptive family has a happier ending – and middle, and almost-beginning – than would otherwise be the case. And even though it’s undoubtedly harder to love someone else’s biological child than your own – why else would stepmothers have such a wicked reputation in folk wisdom? – there are innumerable such families, such kids. But to say this is as good as family bonds that never fractured in the first place is to confuse the contingent with an absolute good. Like claiming that fantastic orthopaedic surgery after a major accident is as good as never having had the accident in the first place.
"The social pressure to be grateful prevents the sheer effort of being an adoptee from being talked about
"The new adoptive family, forming like a scar, is built on loss and breakage. It has to try and heal each corner of its triad: biological parents who have lost (or chosen to lose) their kids, adoptive parents who are often dealing with infertility and the loss of the dream of ‘kids of their own’, and an adoptee who will grow up without the restful privilege of a family that is ‘their own’."
Comments
13 shots will do that to you...
https://neurosciencenews.com/glutamate-trna-alzheimers-26098/
Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization
Highlights
Aging induces cytoplasmic localization of angiogenin to produce Glu-5′tsRNA-CTC
Glu-5′tsRNA-CTC disrupts mitochondrial translation and cristae organization
Cristae ultrastructure is required to maintain glutamate homeostasis in the brain
ASO targeting Glu-5′tsRNA-CTC rescues memory decline in aged mice
Struggling with this now, so I find it informative, got to be my own advocate.
European Society of Endocrinology and Endocrine Society Joint Clinical Guideline: Diagnosis and Therapy of Glucocorticoid-induced Adrenal Insufficiency
https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgae250/7667842
"A recent study reports something strange: When mice with Alzheimer's disease inhale menthol, their cognitive abilities improve. It seems the chemical compound can stop some of the damage done to the brain that's usually associated with the disease."
https://www.sciencealert.com/unexpected-connection-between-menthol-and-alzheimers-discovered-in-mice
Who the hell came up with the idea of giving mice with alzheimers a pack of menthols?
Trapped in the People's Communist Republic of Massachusetts.
That's Kool. ;-)
Hmm, might need to rub some Vicks VapoRub™ on my upper lip.
Organisms in sauerkraut protect gut against antibiotics
The minuscule viruses that infect beneficial bacteria living in sauerkraut can be used to help maintain a healthy gut during treatment with antibiotics, a new study in mice suggests.
Yogurt is often thought of as a good source of healthy bacteria for the gut. All bacteria, including those in our intestines and in the food we eat, are infected by such viruses, known as phages.
Sauerkraut contains even more bacteria than yogurt, as long as it has not been pasteurized or treated with preservatives, the researchers said in a presentation at the Digestive Disease Week meeting in Washington.
To make the sauerkraut, researchers fermented cabbage in a salt solution, then removed the bacteria from the sauerkraut juice and purified the phages.
Next, the researchers gave antibiotics to mice, to disrupt the balance of their healthy gut bacteria. Antibiotics typically kill off healthy bacteria and leave room for disease-causing bacteria to take their place, explained study leader Cristina Coffman of The Biomedical Research Institute of New Mexico in Albuquerque.
A few days later, some of the mice were fed the bacteria-infecting viruses from the sauerkraut juice, in their drinking water. Two weeks later, proportions of healthy gut bacteria were found to be depleted in the untreated mice, but the sauerkraut phages had prevented this disruption in the treated mice, the researchers found.
“In addition to this effect on the microbiome, sauerkraut (phages) also had an interesting biologic impact” the researchers said. Weight gain associated antibiotic treatment appeared to be blocked by sauerkraut phages, they said.
The researchers tested a mixed population of phages against the effects of five different antibiotics, Coffman said.
“We are hoping to learn more about how the phages shape the bacteria populations in the intestines and to find therapeutic uses for the phages,” Coffman said.
" Judgment Pray" By John Sanford. A Lucas Davenport and that F u king Flowers novel 2023. Davenport is now driving a Porsche Cayenne hybrid.
Interesting agglomerative news source
https://www.semafor.com/
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in 2023
https://www.sciencedirect.com/science/article/pii/S1568997223000216?via=ihub
"In a decade’s time, we may look back at 2024 as the golden age of the web, when most of it was quality human-generated content, before the bots took over and filled the web with synthetic and increasingly low-quality AI-generated content."
https://theconversation.com/eat-a-rock-a-day-put-glue-on-your-pizza-how-googles-ai-is-losing-touch-with-reality-230953
Another massive breach...
Ticketmaster hacked. Breach affects more than half a billion users.
Emails, phone numbers, addresses, and even financial details have allegedly been exposed by a notorious hacker group.
https://mashable.com/article/ticketmaster-data-breach-shinyhunters-hack
I take The Epoch Times articles with a grain of salt but this is interesting speculation
Is Gain-of-Function Responsible for the Bird Flu Jump to Cows and Humans?: https://www.theepochtimes.com/health/bird-flu-jumps-twice-to-humans-how-concerned-we-should-be-5648232?
The Collapse Is Coming. Will Humanity Adapt?
An evolutionary biologist and a science fiction writer walk into a bar … and mull over survival.
https://nautil.us/the-collapse-is-coming-will-humanity-adapt-626051/
"Shifting gears to another key point in the book: democracy, which you describe as the one form of government that allows the possibility of change without violence. But you also admit, and this is a quote: “Our governance systems—long ago co-opted as instruments for amplified personal power— have become nearly useless, at all levels, from the United Nations to the local city council. Institutions established during 450 generations of unresolvable conflict cannot facilitate change because they are designed to be agents of social control, maintaining what philosopher John Rawls called ‘the goal of the well-ordered society.’ They were not founded with global climate change, the economics of well-being, or conflict resolution in mind.”
So what you are essentially saying here is that anyone trying to adopt the Darwinian principles that you and Sal are advocating is going to be going up against established societal structures, which makes you, by definition, an enemy of the state.
Yes."
Bronstein described the affected sea urchin species as the "lawn mowers" of coral reefs, since they remove algae that otherwise blocks sunlight, allowing the coral to thrive.
In the Gulf of Aqaba, no other creature has taken over that role and Bronstein's team is already seeing extensive growth in algae cover.
"When mortalities started in the Red Sea, they were so strong and so abrupt and so violent that the first thoughts were this must be some kind of pollution, or something very severe but very local," he said.
Then the phenomenon was seen at a wharf farther south in Sinai where a ferry from Aqaba docks. Two weeks later it spread another 70 kms (44 miles). They described thousands of skeletons of the once dominant species rolling on the sea bottom.
There is no known way to stop the disease, Bronstein said. But there is still a chance to create an isolated population, or broodstock, of the sea urchins remaining elsewhere that could hopefully be reintroduced later on.
https://www.reuters.com/business/environment/sea-urchin-pandemic-spreads-beyond-red-sea-endangering-coral-reefs-2024-06-07/
They weren't wearing masks and keeping six feet apart.
Trapped in the People's Communist Republic of Massachusetts.
https://aeon.co/essays/in-memory-of-all-that-i-lost-when-tinnitus-took-away-my-silence
Mathematicians Are Excited About a Newly Discovered Shape
The unique geometric shape maintains a constant width regardless of the dimension it's measured in.
As reported by New Scientist, at higher dimensions the shape will be proportionally smaller than the sphere of the equivalent dimension. And as New Scientist also points out, the shape can roll smoothly like a wheel even though it’s not round.
https://gizmodo.com/constant-width-shape-mathematicians-solve-puzzle-1851547089?mc_cid=a5b36e864c&mc_eid=965c24ad20
I would go read that but I can already tell it'll make my brain hurt, so I won't.
The shape in two dimensions reminded me of the rotor of a rotary engine.
There's a wiki history page on Wanklel engines. Interesting read. I found this application interesting...
"The Wankel design is used in the seat belt pre-tensioner system[205] in some Mercedes-Benz[206] and Volkswagen[207] cars. When the deceleration sensors detect a potential crash, small explosive cartridges are triggered electrically, and the resulting pressurized gas feeds into tiny Wankel engines, which rotate to take up the slack in the seat belt systems, anchoring the driver and passengers firmly in the seat before a collision.[208]"
https://en.wikipedia.org/wiki/Wankel_engine
"About 13.8 billion years ago, the entire cosmos consisted of a tiny, hot, dense ball of energy that suddenly exploded.
That’s how everything began, according to the standard scientific story of the Big Bang, a theory that first took shape in the 1920s. The story has been refined over the decades, most notably in the 1980s, when many cosmologists came to believe that in its first moments, the universe went through a brief period of extraordinarily fast expansion called inflation before settling into a lower gear.
That brief period is thought to have been caused by a peculiar form of high-energy matter that throws gravity into reverse, “inflating” the fabric of the universe exponentially quickly and causing it to grow by a factor of a million billion billion in less than a billionth of a billionth of a billionth of a second. Inflation explains why the universe appears to be so smooth and homogeneous when astronomers examine it at large scales.
But if inflation is responsible for all that can be seen today, that raises the question: What, if anything, came before?"
https://www.quantamagazine.org/mathematicians-attempt-to-glimpse-past-the-big-bang-20240531/
Someone mentioned this quote in the comments for the above article...
Positive: "being wrong at the top of one's voice"
--Ambrose Bierce
https://nypost.com/2024/06/23/world-news/korean-air-passenger-have-nose-bleeds-after-cabin-pressure-system-malfunctions/
Might want to sell your Boeing stocks, lol.
Right now " Broken Prey " by John Sandford.
Tried to read a new Reacher book " The Secret" by Lee Child's son Andrew Child. Well, Andrew ain't got the writing skill as his dad. Lost interest after two chapters.
Starting the series.
"We are at risk of losing this essential capability that I call receptivity,” says Davis, the managing director of Toronto-based leadership consulting firm Russell Reynolds Associates. “It’s the ability to have good judgment, to have insight about people, and it’s a major concern.”
Technology, social media and artificial intelligence are to blame, Davis adds: People rely so much on their their phones that they’re increasingly unable to make judgment calls on their own. “It’s a cognitive ability that you need to actually exercise in order to not lose it,” he says.
https://www.cnbc.com/2024/06/26/technology-reliance-causes-loss-of-cognitive-ability-psychologist.html
The dumbing down of America's youth and others.
The adoption paradox
"In truth, it can only ever be a happier ending. Of course, every kid who escapes institutional care to grow up in a loving adoptive family has a happier ending – and middle, and almost-beginning – than would otherwise be the case. And even though it’s undoubtedly harder to love someone else’s biological child than your own – why else would stepmothers have such a wicked reputation in folk wisdom? – there are innumerable such families, such kids. But to say this is as good as family bonds that never fractured in the first place is to confuse the contingent with an absolute good. Like claiming that fantastic orthopaedic surgery after a major accident is as good as never having had the accident in the first place.
"The social pressure to be grateful prevents the sheer effort of being an adoptee from being talked about
"The new adoptive family, forming like a scar, is built on loss and breakage. It has to try and heal each corner of its triad: biological parents who have lost (or chosen to lose) their kids, adoptive parents who are often dealing with infertility and the loss of the dream of ‘kids of their own’, and an adoptee who will grow up without the restful privilege of a family that is ‘their own’."
https://aeon.co/essays/even-a-happy-adoption-is-founded-on-an-unstable-sense-of-self