Thanks for the edit @peter4jc , about halfway through the 2nd paragraph I was thinking "No, no, put it in hot water!" John beat me to it.
WARNING: The above post may contain thoughts or ideas known to the State of Caliphornia to cause seething rage, confusion, distemper, nausea, perspiration, sphincter release, or cranial implosion to persons who implicitly trust only one news source, or find themselves at either the left or right political extreme. Proceed at your own risk.
"If you do not read the newspapers you're uninformed. If you do read the newspapers, you're misinformed." -- Mark Twain
This is the end result, a good quart of yummy goodness w/ plenty of Curcumin and CoQ10. And not curcumin stains on me or the kitchen; that's a small miracle as that stuff will turn anything yellow and it's a **** to get the stains out. The other glitch was that curcumin must be heavier than CoQ10 and it wanted to settle to the bottom, so until it set up I had to stir it every 5 or 10 min. Hopefully, starting back up on the CoQ10 alleviates the recent spat of low energy and fatigue.
be aware that the bioavailability of oral dose curcurmin is extremely low. I've read that adding piperine (black pepper is a source) increases absorption significantly:\
Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4 h. Concomitant administration of piperine 20 mg/kg increased the serum concentration of curcumin for a short period of 1-2 h post drug. Time to maximum was significantly increased (P < 0.02) while elimination half life and clearance significantly decreased (P < 0.02), and the bioavailability was increased by 154%. On the other hand in humans after a dose of 2 g curcumin alone, serum levels were either undetectable or very low. Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%. The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.
This is the end result, a good quart of yummy goodness w/ plenty of Curcumin and CoQ10. And not curcumin stains on me or the kitchen; that's a small miracle as that stuff will turn anything yellow and it's a **** to get the stains out. The other glitch was that curcumin must be heavier than CoQ10 and it wanted to settle to the bottom, so until it set up I had to stir it every 5 or 10 min. Hopefully, starting back up on the CoQ10 alleviates the recent spat of low energy and fatigue.
When did this low energy and fatigue start? Are you taking a statin?
If you quote me do the @TX98Z28 in your text or I won't be notified of your quote, Thanks.
When did this low energy and fatigue start? Are you taking a statin?
The fatigue has been a gradual onset for the most part. There were a few days last week where it was accompanied by a shortness of breath after mild exertion, and that was what was concerning me. I was warned a year ago that fatigue was an accepted side-effect of beta-blockers, so me now feeling like I'm 65 is normal. Up until 18mos. ago I felt like I was 55; now I don't even feel like 65 until after a couple of cups of coffee. And yes, 80mg of Atorvastatin, once a day.
When did this low energy and fatigue start? Are you taking a statin?
The fatigue has been a gradual onset for the most part. There were a few days last week where it was accompanied by a shortness of breath after mild exertion, and that was what was concerning me. I was warned a year ago that fatigue was an accepted side-effect of beta-blockers, so me now feeling like I'm 65 is normal. Up until 18mos. ago I felt like I was 55; now I don't even feel like 65 until after a couple of cups of coffee. And yes, 80mg of Atorvastatin, once a day.
Hmmm could very well be the high dose of the statin. 80mg is a lot for Lipitor, highest dose they make I believe. The shortness of breath is concerning to me. I just started Crestor 5mg, hoping it kicks the LDL down without to many side effects.
If you quote me do the @TX98Z28 in your text or I won't be notified of your quote, Thanks.
Finally got around to moving into the new 120 Qt cooler the wife got me for Christmas. Bad news I need another I didn’t realize how many bags of sticks I had squirreled away with Boveda packs in my closet.
Guess I will need to find some BOTL to send a few to.
If you want to bomb me send it to Tony @0patience
If you are a newbie I got Dem nachos....
Day three of jury duty selection. They randomly picked me as juror #1. They haven't released anyone yet. Looks like this would involve most of February.
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I got the shop vac out and cleaned under some benches I haven't dealt with for years. I found a file handle, a nice drawing compass I lost a couple of years ago, a rat tail file I lost last year, a couple of drill bits, lots of wood shavings and bits of sand paper and dust. I'm going to stick my big magnet under the rest of the benches and see what treasure I can turn up.
I got the shop vac out and cleaned under some benches I haven't dealt with for years. I found a file handle, a nice drawing compass I lost a couple of years ago, a rat tail file I lost last year, a couple of drill bits, lots of wood shavings and bits of sand paper and dust. I'm going to stick my big magnet under the rest of the benches and see what treasure I can turn up.
All those files under there makes it sound like your rodents are making a break for it.
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That was a great Super Bowl. I thought KC was screwed then just as predicted (based on their recent comeback wins) they suddenly woke up and spanked some Niner behind.
Turned down an awful sounding SB party to go to my favorite cigar lounge and watch it there. Amazing that just a month or so ago I was intimidated to go there. Sat at the bar with a bunch of guys I didn't know (out of the half dozen or so times I've visited so far it was actually the only night that I was the only female customer, weird lol) and enjoyed a stick, a Coke, and a good game.
It's funny that pirates were always going around searching for treasure, and they never realized that the real treasure was the fond memories they were creating. - Jack Handey
Read the 6 more countries banned thread. Laughed a lot.
WARNING: The above post may contain thoughts or ideas known to the State of Caliphornia to cause seething rage, confusion, distemper, nausea, perspiration, sphincter release, or cranial implosion to persons who implicitly trust only one news source, or find themselves at either the left or right political extreme. Proceed at your own risk.
"If you do not read the newspapers you're uninformed. If you do read the newspapers, you're misinformed." -- Mark Twain
I stopped at the post office this morning to mail out lotto winnings. This time of year up here in the NC mountains you can order and have live chicks mailed to your door. The was a commotion in the back of the PO and I heard someone say " there's another one" One of the crates of chickens had broken open and three post workers were chasing down the chicks. Never a dull moment around here.
Comments
bake cookies (flour and water only) on a fiberglass tray @500f.
Trapped in the People's Communits Republic of Massachusetts.
"If you do not read the newspapers you're uninformed. If you do read the newspapers, you're misinformed." -- Mark Twain
I know, You're a big dog and I'm on the list.
Let's eat, GrandMa. / Let's eat GrandMa. -- Punctuation saves lives
It'll be fine once the swelling goes down.
This is the end result, a good quart of yummy goodness w/ plenty of Curcumin and CoQ10. And not curcumin stains on me or the kitchen; that's a small miracle as that stuff will turn anything yellow and it's a **** to get the stains out. The other glitch was that curcumin must be heavier than CoQ10 and it wanted to settle to the bottom, so until it set up I had to stir it every 5 or 10 min. Hopefully, starting back up on the CoQ10 alleviates the recent spat of low energy and fatigue.
Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers.
Author information
Abstract
The medicinal properties of curcumin obtained from Curcuma longa L. cannot be utilised because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. In this study, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated on the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone, in the dose 2 g/kg to rats, moderate serum concentrations were achieved over a period of 4 h. Concomitant administration of piperine 20 mg/kg increased the serum concentration of curcumin for a short period of 1-2 h post drug. Time to maximum was significantly increased (P < 0.02) while elimination half life and clearance significantly decreased (P < 0.02), and the bioavailability was increased by 154%. On the other hand in humans after a dose of 2 g curcumin alone, serum levels were either undetectable or very low. Concomitant administration of piperine 20 mg produced much higher concentrations from 0.25 to 1 h post drug (P < 0.01 at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in bioavailability was 2000%. The study shows that in the dosages used, piperine enhances the serum concentration, extent of absorption and bioavailability of curcumin in both rats and humans with no adverse effects.
https://www.ncbi.nlm.nih.gov/pubmed/9619120
https://nutritionfacts.org/2015/02/05/why-pepper-boosts-turmeric-blood-levels/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918523/
And yes, 80mg of Atorvastatin, once a day.
Bad news I need another I didn’t realize how many bags of sticks I had squirreled away with Boveda packs in my closet.
If you want to bomb me send it to Tony @0patience
If you are a newbie I got Dem nachos....
Just pour some quicksilver under the bench
All those files under there makes it sound like your rodents are making a break for it.
Turned down an awful sounding SB party to go to my favorite cigar lounge and watch it there. Amazing that just a month or so ago I was intimidated to go there. Sat at the bar with a bunch of guys I didn't know (out of the half dozen or so times I've visited so far it was actually the only night that I was the only female customer, weird lol) and enjoyed a stick, a Coke, and a good game.
"If you do not read the newspapers you're uninformed. If you do read the newspapers, you're misinformed." -- Mark Twain